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by José Machado · Alfabia · tapa blanda · ISBN 9788494367977
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El contrato final es una colección de cuentos cortos del autor José Machado, publicado por Alfabia en 2015. Los relatos exploran personajes atormentados y situaciones de contrastes, como el azar contra el destino, la ludopatía y las relaciones sadomasoquistas. Con 186 páginas, esta edición en español ofrece una combinación de análisis psicológico y momentos de violencia y deseo.
Machado–Joseph disease (MJD), also known as Machado–Joseph Azorean disease, Machado's disease, Joseph's disease or spinocerebellar ataxia type 3 (SCA3), is a rare autosomal dominantly inherited neurodegenerative disease that causes progressive cerebellar ataxia, which results in a lack of muscle control and coordination of the upper and lower extremities. The symptoms are caused by a genetic mutation that results in an expansion of abnormal "CAG" trinucleotide repeats in the ATXN3 gene that results in an abnormal form of the protein ataxin which causes degeneration of cells in the hindbrain. Some symptoms, such as clumsiness and rigidity, make MJD commonly mistaken for drunkenness or Parkinson's disease.
